The four-year survival rate was 58 percent in the silymarin group and 39 percent in the placebo group. What is the dose of Legalon® (Silymarin) for a child? Generic Name : Silymarin Pronunciation : SILL-ee-MAR-inn Latest prescription information about Silymarin. It may be unsafe for your child. A 30-day study in rats found no toxicity at 150 mg/kg/day. Search drug, interactions and image information in China, Hong Kong, Taiwan, Malaysia, Singapore, Philippines, Vietnam, Thailand, Indonesia, India & USA Common side effects of Silymarin : Abdominal bloating, diarrhea, flatulence, loss of appetite, nausea and stomach upset. The reduced death rate among those taking silymarin was most pronounced in the alcoholic cirrhosis subgroup. The combination of silybin and phosphatidylcholine in Liverprime is three times better absorbed than plain Silymarin. There were no side effects from silymarin.4 70mg-capsule: 2 capsule/time x 3 times a day. Subjects received 140 mg silymarin three times a day for 41 months. In people with liver disease, the typical dosage was higher, around 1.3 g/day of the standardized for 6 – 8 weeks (divided into 3 doses during the day). In dogs given oral citicoline 1.5 g/kg daily for 6 months, no biochemical, neurological, or histological toxicity was found.1. 1. 140mg-capsule: 1 capsule/time x 3 times a day. It can cause nausea, vomiting, and diarrhea or constipation. Silymarin is a fruit extract from the plant milk thistle that is claimed to be a free radical scavenger and to have hepatoprotectant properties; it has been used in various liver … Schauss AG, Somfai-Relle S, Financsek I, et al. Silymarin may intensify the effects of drugs that decrease blood sugar levels (hypoglycemic drugs). Side Effects & Safety When taken by mouth: N-acetyl cysteine is LIKELY SAFE for most adults. References. Silymarin promotes liver cell protein synthesis and decreases the oxidation of glutathione. Phytosome technology improves the bioavailability of silybin as it is complexed with phosphatidylcholine. The silymarin exerts membrane-stabilizing and antioxidant activity, it promotes hepatocyte regeneration; furthermore it reduces the inflammatory reaction, and inhibits the fibrogenesis in the liver. 140 Tablet:Role of Silymarin- Powerful antioxidant; Used to protect liver cells (and other cells in the body and brain) from toxins. Click here for full details on all the markets covered. These results have been established by experimental and clinical trials. The typical silymarin dosage used in most studies was ~420 mg/day divided into 2 or 3 doses. Beneficial in a number of diseases involving liver disease; Direction for use/Dosage: – Take as directed by the physician The dosage has not been established in pediatric patients. 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